《植物生理学报》 2013, 49(1): 24-28

逆境胁迫下甘油醛-3-磷酸脱氢酶功能多元化的研究进展

张霞, 王艳, 张富春*

新疆大学生命科学与技术学院, 新疆生物资源与基因工程重点实验室, 乌鲁木齐830046

通信作者：张富春；E-mail: zfcxju@gmail.com；Tel: 0991-8583517

摘　要：

糖酵解是动植物以及微生物细胞中葡萄糖分解产生能量的共同代谢途径, 而甘油醛-3-磷酸脱氢酶(GAPDH)作为糖酵解途径中的一种关键酶, 被认为是只存在于细胞质中的管家基因产物。但近年来的研究表明GAPDH mRNA和蛋白质水平会随着各种环境因素的影响而发生变化, 并具有不同的亚细胞定位以及多元化的生理功能。本文综述逆境胁迫下GAPDH在不同生物体细胞中的不同功能的相关作用机制。

关键词：甘油醛-3-磷酸脱氢酶; 功能多元化; 逆境胁迫

收稿：2012-12-03   修定：2013-01-04

资助：“973”计划前期研究专项(2012CB722204)和新疆生物资源基因工程重点实验室开放课题(XJDX0201-2012-05)。GAPDH在不同生物体细胞中的不同功能的相关作用机制。

Advances in the Research of the Diversified Functions of Glyceraldehyde-3-Phosphate Dehydrogenase under Unfavorable Conditions

ZHANG Xia, WANG Yan, ZHANG Fu-Chun*

Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China

Corresponding author: ZHANG Fu-Chun; E-mail: zfcxju@gmail.com; Tel: 0991-8583517

Abstract:

Glycolytic pathway is a common metabolic pathway for energy generation in the animal, plant and microbial cells. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key enzyme in this pathway, and is considered to be a housekeeping gene and only exist in the cytoplasm. However, researches in re-sent years suggest that both the levels of mRNA and protein of GAPDH vary with the influence of various environmental factors, and GAPDH also shows various subcellular localization and diversified physiolog-ical functions. In this paper, the mechanisms of GAPDH with distinctive functions in different organisms under unfavorable conditions are summarized.

Key words: glyceraldehyde-3-phosphate dehydrogenase; diversified function; unfavorable conditions